UNOTRE Ripiglio

Fatti meglio

Having fun is fun but takes a toll on your body.

Ripiglio is a concentrate of substances obtained from plants to counterbalance the adverse effects of having fun.

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Riduci i sintomi dei postumi

Reduce hangover symptoms

Speed ethanol breakup, alleviate headaches, contrast inflammations

Prenditi cura dei tuoi organi interni

Take care
of your internal organs

Fight the free radicals released by abuses, protect liver cells

Combatti la dipendenza da sostanze

Battle substance
addiction

Studies have shown the ingredients help reduce substance abuse

What’s inside

500mg

Kudzu

A root used for 2.000+ years for treating hangover, and according to modern research, helpful in reducing the consumption of alcohol and cocaine

300mg

Desmodium

A plant that protects liver cells, contrasts oxidative stress and free radicals, speeds ethanol breakup

200mg

Parthenium

A plant that reduces headache and has anti-inflammatory properties

Chlorophyll, green tea, coenzyme Q10, B vitamins B and magnesium

They reintegrate minerals and vitamins and carry out an antioxidant action against the effects of substances

UNOTRE Ripiglio Pack

Recover

Take a dose of Ripiglio before going out, or if you had an unexpected session of partying, before going to bed.

Or, whenever you feel like rebalancing some excesses by helping your liver and body.

39€ for 6 50ml doses

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Having fun

Substance intoxication is a type of substance use disorder which is potentially maladaptive and impairing, but reversible, and associated with recent use of a substance.

If the symptoms are severe, the term “substance intoxication delirium” may be used. Slang terms include: getting high (generic), being stoned, cooked, or blazed, and many more specific slang terms for particular intoxicants. Alcohol intoxication is graded in intensity from buzzed, to tipsy (all the way up to drunk, hammered, smashed,wasted, destroyed, shitfaced and a number of other terms).

Fig. 1.
Severe symptoms

What alcohol does to your body

Alcohol is metabolized by a normal liver at the rate of about 8 grams of pure ethanol per hour. 8 grams or 10 ml (0.34 US fl oz) is one British standard unit. Ethanol is metabolised to acetaldehyde by alcohol dehydrogenase (ADH), which is found in many tissues, including the gastric mucosa. Acetaldehyde is metabolised to acetate by acetaldehyde dehydrogenase (ALDH), which is found predominantly in liver mitochondria. Acetate is used by the muscle cells to produce acetyl-CoA using the enzyme acetyl-CoA synthetase, and the acetyl-CoA is then used in the citric acid cycle.

Fig. 2.
Alcohol metabolism

Ethanol’s acute effects are due largely to its nature as a central nervous system depressant, and are dependent on blood alcohol concentrations:

  • 20–79 mg/dL: Impaired coordination and euphoria
  • 80–199 mg/dL – Binge drinking: Ataxia, poor judgement, labile mood. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines the term “binge drinking” as a pattern of drinking that brings a person’s blood alcohol concentration (BAC) to 0.08 g/dL or above
  • 200–299 mg/dL: Marked ataxia, slurred speech, poor judgement, labile mood, nausea and vomiting
  • 300–399 mg/dL: Stage 1 anaesthesia (“blackout”), memory lapse, labile mood
  • 400+ mg/dL: Respiratory failure, coma

Alcohol can intensify the sedation caused by other central nervous system depressants such as barbiturates, benzodiazepines, opioids, nonbenzodiazepines/Z-drugs (such as zolpidem and zopiclone), antipsychotics, sedative antihistamines, and certain antidepressants. It interacts with cocaine in vivo to produce cocaethylene, another psychoactive substance.

Prolonged heavy consumption of alcohol can cause significant permanent damage to the brain and other organs:

  • alcohol can cause permanent brain damage. An extreme example is Wernicke–Korsakoff syndrome
  • during the metabolism of alcohol via the respective dehydrogenases, NAD (nicotinamide adenine dinucleotide) is converted into reduced NAD. Normally, NAD is used to metabolize fats in the liver, and as such alcohol competes with these fats for the use of NAD. Prolonged exposure to alcohol means that fats accumulate in the liver, leading to the term ‘fatty liver’. Continued consumption (such as in alcoholism) then leads to cell death in the hepatocytes as the fat stores reduce the function of the cell to the point of death. These cells are then replaced with scar tissue, leading to the condition called cirrhosis
  • discontinuation of alcohol after extended heavy use and associated tolerance development (resulting in dependence) can result in withdrawal. Alcohol withdrawal can cause confusion, anxiety, insomnia, agitation, tremors, fever, nausea, vomiting, autonomic dysfunction, seizures, and hallucinations. In severe cases, death can result. Delirium tremens is a condition that requires people with a long history of heavy drinking to undertake an alcohol detoxification regimen.

One factor that has been suggested as playing a central role in many pathways of alcohol–induced damage, and which has been the focus of much research, is the excessive generation of molecules called free radicals, which can result in a state called oxidative stress. Particularly important are the actions of a class of oxygen–containing free radicals known as reactive oxygen species (ROS). ROS can damage or cause complete degradation (i.e., peroxidation) of essential complex molecules in the cells, including fat molecules (i.e., lipids), proteins, and DNA. Both acute and chronic alcohol exposure can increase production of ROS and enhance peroxidation of lipids, protein, and DNA, as has been demonstrated in a variety of systems, cells, and species, including humans.

What cocaine does to your body

Cocaine increases alertness, feelings of well-being, euphoria, energy, competence, sociability, and sexuality. Common side effects include anxiety, increased temperature, paranoia, restlessness, and teeth grinding. With prolonged use, the drug can cause insomnia, weight loss, anorexia, tachycardia, hallucinations, and paranoid delusions. Possible lethal side effects include rapid heartbeat, abnormal heart rhythms, tremors, convulsions, markedly increased core temperature, renal failure, heart attack, stroke and heart failure.

Fig. 3.
Cocaine

Depression with suicidal ideation may develop in heavy users. Finally, a loss of vesicular monoamine transporters, neurofilament proteins, and other morphological changes appear to indicate a long-term damage to dopamine neurons. Chronic intranasal usage can degrade the cartilage separating the nostrils (the septum nasi), which can eventually lead to its complete disappearance.

Cocaine-induced cardiovascular disorders such as hypertension, thrombosis, myocardial dysfunction, cardiac dysrhythmias and endocarditis have received widespread attention in the context of cocaine abuse. The number of sudden deaths from cardiac causes, including myocardial infarction, ventricular tachyarrhythmia or aortic dissection, is also increasing. Evidence has revealed that cardiac oxidative stress is a prominent early event of cocaine administration, which severely compromises the cardiac antioxidant cellular system and causes cardiac antioxidant cellular system injuries. Oxidative damage such as peroxidation of membrane phospholipids and depletion of nonenzymatic antioxidants such as glutathione have been found in the myocardium of chronic cocaine-treated animals and in patients. The data indicate that cocaine administration compromised the heart’s antioxidant defense system.

Cocaine can also cause a wide array of kidney diseases and kidney failure.

What alcohol and cocaine together do to your body

Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood. In 1885, cocaethylene was first synthesized (according to edition 13 of the Merck Index), and in 1979, cocaethylene’s side effects were discovered.

Fig. 4.
Cocaethylene

Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites—benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaine’s metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, rather than undergoing hydrolysis with water, which results in the production of cocaethylene.

Cocaethylene increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter.

In most users, cocaethylene produces euphoria and has a longer duration of action than cocaine. Some studies suggest that consuming alcohol in combination with cocaine may be more cardiotoxic than cocaine and “it also carries an 18 to 25 fold increase over cocaine alone in risk of immediate death”.

Fig. 5.
Risk

Counteract

“Medicine”

Prehistoric medicine incorporated plants (herbalism), animal parts, and minerals. In many cases these materials were used ritually as magical substances by priests, shamans, or medicine men. Well-known spiritual systems include animism (the notion of inanimate objects having spirits), spiritualism (an appeal to gods or communion with ancestor spirits); shamanism (the vesting of an individual with mystic powers); and divination (magically obtaining the truth).

Traces of therapeutic activities in China date from the Shang dynasty (14th–11th centuries BCE). Shennong Ben Cao Jing is the earliest medical book in China. This book was written in the Eastern Han Dynasty between 200 and 250CE. It did not only have one author. Instead, it was the combined effort of many medical scientists in the Qin and Han Dynasties who summarized, collected and compiled the results of pharmacological experience at their time periods. It was the first systematic summary of Chinese herbal medicine. Most of the pharmacological theories and compatibility rules and the proposed “seven emotions and harmony” principle have played a huge role in the practice of medicine for thousands of years in Chinese medicine. Therefore, it has long been a textbook for doctors and pharmacists to learn Chinese pharmacy, and it is also one of the necessary books for medical workers in China.

Fig. 6.
Shennong (神農, Shénnóng, which can be variously translated as “Divine Farmer” or “Divine Peasant”, “Agriculture God”) has been thought to have taught the ancient Chinese not only their practices of agriculture, but also the use of herbal drugs.

“Herbs: Superior Class – Bai Tu Huo (Herba Cynanchi Caudati) is bitter and balanced. It mainly treats bites by snakes and insects like bees, rabid dog bite, vegetable and meat toxins, gu toxins, and demonic influx. Its other name is Bai Ge (White Kudzu Vine). It grows in mountains and valleys.”

Shennong Ben Cao Jing, the earliest medical book in China

Kudzu

Kudzu (/ˈkʊdzuː/; also called Japanese arrowroot) is a group of plants in the genus Pueraria, in the pea family Fabaceae, subfamily Faboideae. They are climbing, coiling, and trailing perennial vines native to much of eastern Asia, Southeast Asia, and some Pacific islands. The name is derived from the Japanese name for the plant East Asian arrowroot (Pueraria montana var. lobata), クズ or 葛 (kuzu).

Rich in quercitin, isoflavones and antioxidants, the use of this plant is so common that it has long been used as a therapeutic food, capable, with its properties, of intervening on many problems. In the East it is used as a natural remedy for hangover.

According to some studies kudzu alleviates the effects of alcoholism and other addictions. During an experiment people to whom it was given kudzu as a drink reduced the amount of alcohol consumed daily and, at the same time, increased the consecutive days of abstaining from drinking. No one knows exactly why it works but it’s thought to be because it increase blood flow, which allows you to feel earlier the effects of alcohol and stop drinking after fewer drinks.

An extract of the kudzu vine being developed to treat alcoholism may also help treat cocaine addiction, according to researchers at Gilead Sciences Inc. Tests on rats showed the drug could stop them from giving themselves cocaine, the Gilead team reported in the journal Nature Medicine.

Fig. 7.
Rats and cocaine

Kudzu is also commonly used to relieve stress and calm intestine and digestive system’s irritation. It’s known for its natural ability to act as gastroprotective, recommended in case of gastroesophageal reflux or heartburn. Kudzu acts by dabbing and absorbing excess of gastric juices; soothes the gastric walls and acts as anti-inflammatory. At the same time improves digestive functions. It’s able to stop constipation and diarrhea, compacting the feces; In conclusion kudzu rebalances the intestine.

Desmodium

Desmodium (Desmodium Desv., 1813) is a genus of plants in the Fabaceae family (or Leguminosae). It has the capacity to protect hepatic cells, preventing glucose-induced oxidative stress and inhibiting the action of monooxygenase enzyme, thereby blocking the production of free radicals, most produced following alcohol abuse.

Parthenium

Parthenium (Tanacetum parthenium (L.) Sch.Bip., 1844) is a plant in the Asteraceae family. It is particularly effective against headaches. Studies have shown hypotensive and antispasmodic properties at level of the digestive tract, due to the action on smooth muscles. It has also a mild tranquilizing effect that would facilitate sleep, if the plant is taken in the evening. Its anti-inflammatory action also has a good soothing effect on joint pains, including those arising from rheumatoid arthritis.

Chlorophyll

Chlorophyll has antioxidant properties that would help defend the body from negative effects of free radicals. In addition, detoxifying properties have been attributed to it.

Green tea

Buds of leaves and young leaves of green tea contain the highest percentage of antioxidant principles found in nature, useful for counteracting formation of free radicals. Green tea’s polyphenols are anti-radicals, more powerful even than vitamin C and E.

Coenzyme Q10

Intake of food supplements based on coenzyme Q10 is generally indicated to counteract fatigue, asthenia, reduce the feeling of slackness and promote well-being at muscular level, and, by virtue of its antioxidant role, counteract the oxidative stress induced by free radicals.

B vitamins

These vitamins play an essential role in the normal functioning of the nervous system and in gastrointestinal area’s muscle tone. They are also essential for the correct functioning processes of skin and hair, and therefore also scalp, for mouth and eyes and for the proper functioning of the liver.

Magnesium

Magnesium participates in many reactions that take place in cells. It’s the cofactor of more than 300 enzymes that control very different processes, from protein synthesis to functioning of muscles and nerves, up to control of blood sugar and blood pressure.

Reference

Alcohol, Oxidative Stress, and Free Radical Damage
https://pubs.niaaa.nih.gov/publications/arh27-4/277-284.htm

Role of oxidative stress in cocaine-induced cardiotoxicity and cocaine-related death
https://www.ncbi.nlm.nih.gov/pubmed/22856662

From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction
https://www.ncbi.nlm.nih.gov/pubmed/26022266

A Single Dose of Kudzu Extract Reduces Alcohol Consumption in a Binge Drinking Paradigm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510012/

Kudzu Root Extract Does Not Perturb the Sleep/Wake Cycle of Moderate Drinkers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233215/

Harmful and beneficial aspects of Parthenium hysterophorus: an update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339593/

Safety of Desmodium adscendens extract on hepatocytes and renal cells. Protective effect against oxidative stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566765/

Chemical Composition and, Cellular Evaluation of the Antioxidant Activity of Desmodium adscendens Leaves
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957201/

Some secondary plant metabolites in Desmodium adscendens and their effects on arachidonic acid metabolism
https://www.ncbi.nlm.nih.gov/pubmed/1438471

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UNOTRE Ripiglio

Ripiglio

A concentrate of substances of vegetal origin contrasting the undesired effects of partying.

39€ for 6 50ml doses

Ok I got it, I’ll buy it