Ripiglio

Fatti meglio

Having fun is fun but takes a toll on your body.

Ripiglio is a concentrate of substances obtained from plants to counterbalance the adverse effects of having fun.

Buy Discover more

Reduce hangover symptoms

Speed ethanol breakup, alleviate headaches, contrast inflammations

Take care
of your internal organs

Fight the free radicals released by abuses, protect liver cells

Battle substance
addiction

Studies have shown the ingredients help reduce substance abuse

What’s inside

500mg

Kudzu

A root used for 2.000+ years for treating hangover, and according to modern research, helpful in reducing the consumption of alcohol and cocaine

300mg

Desmodium

A plant that protects liver cells, contrasts oxidative stress and free radicals, speeds ethanol breakup

200mg

Parthenium

A plant that reduces headache and has anti-inflammatory properties

Chlorophyll, green tea, coenzyme Q10, B vitamins B and magnesium

They reintegrate minerals and vitamins and carry out an antioxidant action against the effects of substances

Ripiglio is manufactured in Italy by Laboratori Naturethics, via Leonardo Da Vinci 38, Saronno (VA).

Laboratori Naturethics manufactures according to the GMP (Good Manufacturing Practices) principles. It utilizes state of the art formulations and extractive processes, like cryo-grinding, which thanks to liquid nitrogen and extremely low temperatures (-15°C) protects vegetal tissues and active ingredients from oxidation.

Recover

Take a dose of Ripiglio before going out, or if you had an unexpected session of partying, before going to bed.

Or, whenever you feel like rebalancing some excesses by helping your liver and body.

Keep documenting

Even if these are natural substances it doesn’t mean abusing a remedy is the right way to deal with a problem. If you think you’re using too much alcohol go see a specialist (if you feel shame know there’s nothing wrong in it, but to help you could always use a correct Eyewear).

Having fun

Substance intoxication is a type of substance use disorder which is potentially maladaptive and impairing, but reversible, and associated with recent use of a substance.

If the symptoms are severe, the term “substance intoxication delirium” may be used. Slang terms include: getting high (generic), being stoned, cooked, or blazed, and many more specific slang terms for particular intoxicants. Alcohol intoxication is graded in intensity from buzzed, to tipsy (all the way up to drunk, hammered, smashed,wasted, destroyed, shitfaced and a number of other terms).

What alcohol does to your body

Alcohol is metabolized by a normal liver at the rate of about 8 grams of pure ethanol per hour. 8 grams or 10 ml (0.34 US fl oz) is one British standard unit. Ethanol is metabolised to acetaldehyde by alcohol dehydrogenase (ADH), which is found in many tissues, including the gastric mucosa. Acetaldehyde is metabolised to acetate by acetaldehyde dehydrogenase (ALDH), which is found predominantly in liver mitochondria. Acetate is used by the muscle cells to produce acetyl-CoA using the enzyme acetyl-CoA synthetase, and the acetyl-CoA is then used in the citric acid cycle.

Ethanol’s acute effects are due largely to its nature as a central nervous system depressant, and are dependent on blood alcohol concentrations:

20–79 mg/dL: Impaired coordination and euphoria
80–199 mg/dL – Binge drinking: Ataxia, poor judgement, labile mood. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines the term “binge drinking” as a pattern of drinking that brings a person’s blood alcohol concentration (BAC) to 0.08 g/dL or above
200–299 mg/dL: Marked ataxia, slurred speech, poor judgement, labile mood, nausea and vomiting
300–399 mg/dL: Stage 1 anaesthesia (“blackout”), memory lapse, labile mood
400+ mg/dL: Respiratory failure, coma

Alcohol can intensify the sedation caused by other central nervous system depressants such as barbiturates, benzodiazepines, opioids, nonbenzodiazepines/Z-drugs (such as zolpidem and zopiclone), antipsychotics, sedative antihistamines, and certain antidepressants. It interacts with cocaine in vivo to produce cocaethylene, another psychoactive substance.

Prolonged heavy consumption of alcohol can cause significant permanent damage to the brain and other organs:

alcohol can cause permanent brain damage. An extreme example is Wernicke–Korsakoff syndrome
during the metabolism of alcohol via the respective dehydrogenases, NAD (nicotinamide adenine dinucleotide) is converted into reduced NAD. Normally, NAD is used to metabolize fats in the liver, and as such alcohol competes with these fats for the use of NAD. Prolonged exposure to alcohol means that fats accumulate in the liver, leading to the term ‘fatty liver’. Continued consumption (such as in alcoholism) then leads to cell death in the hepatocytes as the fat stores reduce the function of the cell to the point of death. These cells are then replaced with scar tissue, leading to the condition called cirrhosis
discontinuation of alcohol after extended heavy use and associated tolerance development (resulting in dependence) can result in withdrawal. Alcohol withdrawal can cause confusion, anxiety, insomnia, agitation, tremors, fever, nausea, vomiting, autonomic dysfunction, seizures, and hallucinations. In severe cases, death can result. Delirium tremens is a condition that requires people with a long history of heavy drinking to undertake an alcohol detoxification regimen.

One factor that has been suggested as playing a central role in many pathways of alcohol–induced damage, and which has been the focus of much research, is the excessive generation of molecules called free radicals, which can result in a state called oxidative stress. Particularly important are the actions of a class of oxygen–containing free radicals known as reactive oxygen species (ROS). ROS can damage or cause complete degradation (i.e., peroxidation) of essential complex molecules in the cells, including fat molecules (i.e., lipids), proteins, and DNA. Both acute and chronic alcohol exposure can increase production of ROS and enhance peroxidation of lipids, protein, and DNA, as has been demonstrated in a variety of systems, cells, and species, including humans.

What cocaine does to your body

Cocaine increases alertness, feelings of well-being, euphoria, energy, competence, sociability, and sexuality. Common side effects include anxiety, increased temperature, paranoia, restlessness, and teeth grinding. With prolonged use, the drug can cause insomnia, weight loss, anorexia, tachycardia, hallucinations, and paranoid delusions. Possible lethal side effects include rapid heartbeat, abnormal heart rhythms, tremors, convulsions, markedly increased core temperature, renal failure, heart attack, stroke and heart failure.

Depression with suicidal ideation may develop in heavy users. Finally, a loss of vesicular monoamine transporters, neurofilament proteins, and other morphological changes appear to indicate a long-term damage to dopamine neurons. Chronic intranasal usage can degrade the cartilage separating the nostrils (the septum nasi), which can eventually lead to its complete disappearance.

Cocaine-induced cardiovascular disorders such as hypertension, thrombosis, myocardial dysfunction, cardiac dysrhythmias and endocarditis have received widespread attention in the context of cocaine abuse. The number of sudden deaths from cardiac causes, including myocardial infarction, ventricular tachyarrhythmia or aortic dissection, is also increasing. Evidence has revealed that cardiac oxidative stress is a prominent early event of cocaine administration, which severely compromises the cardiac antioxidant cellular system and causes cardiac antioxidant cellular system injuries. Oxidative damage such as peroxidation of membrane phospholipids and depletion of nonenzymatic antioxidants such as glutathione have been found in the myocardium of chronic cocaine-treated animals and in patients. The data indicate that cocaine administration compromised the heart’s antioxidant defense system.

Cocaine can also cause a wide array of kidney diseases and kidney failure.

What alcohol and cocaine together do to your body

Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood. In 1885, cocaethylene was first synthesized (according to edition 13 of the Merck Index), and in 1979, cocaethylene’s side effects were discovered.

Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites—benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaine’s metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, rather than undergoing hydrolysis with water, which results in the production of cocaethylene.

Cocaethylene increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter.

In most users, cocaethylene produces euphoria and has a longer duration of action than cocaine. Some studies suggest that consuming alcohol in combination with cocaine may be more cardiotoxic than cocaine and “it also carries an 18 to 25 fold increase over cocaine alone in risk of immediate death”.

Counteract

“Medicine”

Prehistoric medicine incorporated plants (herbalism), animal parts, and minerals. In many cases these materials were used ritually as magical substances by priests, shamans, or medicine men. Well-known spiritual systems include animism (the notion of inanimate objects having spirits), spiritualism (an appeal to gods or communion with ancestor spirits); shamanism (the vesting of an individual with mystic powers); and divination (magically obtaining the truth).

Traces of therapeutic activities in China date from the Shang dynasty (14th–11th centuries BCE). Shennong Ben Cao Jing is the earliest medical book in China. This book was written in the Eastern Han Dynasty between 200 and 250CE. It did not only have one author. Instead, it was the combined effort of many medical scientists in the Qin and Han Dynasties who summarized, collected and compiled the results of pharmacological experience at their time periods. It was the first systematic summary of Chinese herbal medicine. Most of the pharmacological theories and compatibility rules and the proposed “seven emotions and harmony” principle have played a huge role in the practice of medicine for thousands of years in Chinese medicine. Therefore, it has long been a textbook for doctors and pharmacists to learn Chinese pharmacy, and it is also one of the necessary books for medical workers in China.

Fig. 6.
Shennong (神農, Shénnóng, which can be variously translated as “Divine Farmer” or “Divine Peasant”, “Agriculture God”) has been thought to have taught the ancient Chinese not only their practices of agriculture, but also the use of herbal drugs.

“Herbs: Superior Class – Bai Tu Huo (Herba Cynanchi Caudati) is bitter and balanced. It mainly treats bites by snakes and insects like bees, rabid dog bite, vegetable and meat toxins, gu toxins, and demonic influx. Its other name is Bai Ge (White Kudzu Vine). It grows in mountains and valleys.”

Shennong Ben Cao Jing, the earliest medical book in China